Get acquainted with CUVRIOR®.

Maintain your copper balance with CUVRIOR

CUVRIOR (trientine tetrahydrochloride) is a Wilson Disease (WD) treatment that helps maintain copper balance in adults with stable disease who are  de-coppered and tolerant to penicillamine.

Copper deficiency may develop following treatment with CUVRIOR. Periodic monitoring by a healthcare professional is required.

Explore greater on-the-go potential

Convenient twice-daily dosing.

Stable at room temperature, so it doesn’t require refrigeration.

Supplied in a portable blister pack.

Scored tablets can be divided in half if needed.

Take CUVRIOR on an empty stomach (at least 1 hour before meals or 2 hours after meals and at least 1 hour apart from any other food, milk, or oral medication).

Interested in financial assistance or insurance support?

The Navigator Program™ could help

The Navigator Program™ is a no cost program available to CUVRIOR patients that provides access support.

Explore Patient Support

Sign up to receive helpful news and updates

Ready for a maintenance therapy  you can take on the go?

CUVRIOR offers twice-daily dosing in a portable blister pack  that doesn't require refrigeration. Learn more about taking CUVRIOR.

INDICATION

CUVRIOR is a prescription medicine used to treat adults with stable Wilson Disease who are de-coppered and able to take penicillamine. Wilson Disease is a condition where the body stores too much copper. CUVRIOR is a chelating medicine which binds copper in the blood stream and eliminates it in the urine to help reduce excess copper in the organs.

IMPORTANT SAFETY INFORMATION

Do not use CUVRIOR if you are allergic to trientine or to any of the ingredients in CUVRIOR.
Your Wilson Disease symptoms could get worse when you start treatment. This could happen because too much copper is removed from the body in a short period of time. Your doctor may need to reduce your dose or stop CUVRIOR treatment.
Copper deficiency may develop following treatment with CUVRIOR. Your doctor will do tests to monitor your urine and blood for copper.
Iron deficiency may develop while taking CUVRIOR. If this happens, your doctor may tell you to take iron supplements for a limited time.
Allergic reactions, such as a rash can occur. If a rash or other allergic reaction occurs, contact your doctor immediately or get emergency help.
The most common side effects are pain in the abdomen, change in bowel habits, rash, hair loss (alopecia), and mood swings.

Take CUVRIOR at least 1 hour apart from any other oral medicine. Tell your doctor about all the medicines you're taking, including over-the-counter medicines, vitamins, and herbal supplements. Avoid taking supplements when taking CUVRIOR. Taking CUVRIOR with mineral supplements (e.g., iron, zinc, calcium, magnesium) can reduce the effectiveness of CUVRIOR. If iron supplementation is necessary, take CUVRIOR at least 2 hours before or 2 hours after taking iron; for other mineral supplements (e.g., zinc, calcium, magnesium), take CUVRIOR at least 1 hour before or 2 hours after. Do not start or stop any medicines while taking CUVRIOR without talking to your doctor.

These are not all the possible side effects of CUVRIOR. You are encouraged to report negative side effects of prescription drugs. Contact Orphalan at 1-800-961-8320 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information.

INDICATION

CUVRIOR is a prescription medicine used to treat adults with stable Wilson Disease who are de-coppered and able to take penicillamine. Wilson Disease is a condition where the body stores too much copper. CUVRIOR is a chelating medicine which binds copper in the blood stream and eliminates it in the urine to help reduce excess copper in the organs.

IMPORTANT SAFETY INFORMATION

Do not use CUVRIOR if you are allergic to trientine or to any of the ingredients in CUVRIOR.
Your Wilson Disease symptoms could get worse when you start treatment. This could happen because too much copper is removed from the body in a short period of time. Your doctor may need to reduce your dose or stop CUVRIOR treatment.
Copper deficiency may develop following treatment with CUVRIOR. Your doctor will do tests to monitor your urine and blood for copper.
Iron deficiency may develop while taking CUVRIOR. If this happens, your doctor may tell you to take iron supplements for a limited time.
Allergic reactions, such as a rash can occur. If a rash or other allergic reaction occurs, contact your doctor immediately or get emergency help.
The most common side effects are pain in the abdomen, change in bowel habits, rash, hair loss (alopecia), and mood swings.

Take CUVRIOR at least 1 hour apart from any other oral medicine. Tell your doctor about all the medicines you're taking, including over-the-counter medicines, vitamins, and herbal supplements. Avoid taking supplements when taking CUVRIOR. Taking CUVRIOR with mineral supplements (e.g., iron, zinc, calcium, magnesium) can reduce the effectiveness of CUVRIOR. If iron supplementation is necessary, take CUVRIOR at least 2 hours before or 2 hours after taking iron; for other mineral supplements (e.g., zinc, calcium, magnesium), take CUVRIOR at least 1 hour before or 2 hours after. Do not start or stop any medicines while taking CUVRIOR without talking to your doctor.

These are not all the possible side effects of CUVRIOR. You are encouraged to report negative side effects of prescription drugs. Contact Orphalan at 1-800-961-8320 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information.